Jose Javier Fernandez

Research

My research focuses on how metabolic pathways regulate immune cell function, with a particular emphasis on dendritic cells (DCs). Using combining molecular and cellular biology approaches, I investigated the signaling pathways that govern immune activation, cytokine production, and metabolic adaptation in response to fungal infection and SARS-CoV-2. The field of immunometabolism is increasingly moving toward integrative multi-omics approaches, enabling comprehensive characterization of metabolic remodeling during immune activation. Recently, we generated transcriptomic and metabolomic datasets describing the metabolic landscape of activated DCs across different T cell contexts.

Curriculum Vitae

I completed my PhD at Instituto de Biomedicina y Genetica Molecular (IBGM) in Valladolid (Spain), specializing on DCs host pathogen interaction and their immunomodulatory roles in fungal and viral infection. Following this,  I was awarded with a two-year postdoctoral fellowship from FUNDAME, to investigate the regulatory “sweet-spot” of DC biology. My current project focused on the role of O-GlcNAcylation in DC metabolism and function, particularly in the context of type 2 immunity.